At around 6 a.m. on Tuesday, June 28, the Days Inn Hotel on S. Main contacted them for a well-being check.
Hotel staff told police they man had not checked out of his room on time. They said the cleaning crew found some property belonging to the man still in the room, but he and his vehicle were nowhere to be found.
Officers identified the man as 66-year-old Larry Weaver, of Pittsburg, Kan.
According to police, his wife said Weaver had been traveling on his black 2013 Harley Davidson Street Glide when he went missing.
Weaver left several personal items in the room that led police to believe something was wrong. Some of the items include his wallet, credit cards, some keys, cellphone, clothing and riding gear.
Currently, police say they are unsure if Weaver had some sort of medical event, an unseen motorcycle crash or even that he may be a victim of foul play.
Weaver is described as 5 feet, 10 inches tall and 185 pounds.
The motorcycle has Kansas license plates: "36A0Y" and hard saddle bags.
As of 4:30 a.m. on Wednesday, June 29, Weaver was still considered missing.
If you see Weaver or his motorcycle, please contact Sikeston DPS at 573-471-4711.